Sex-specific genetic architecture of human disease.
- Authors
- Ober, Carole; Loisel, Dagan A; Gilad, Yoav
- Year
- 2008
- Journal
- Nature reviews. Genetics
- PMID
- 19002143
- DOI
- 10.1038/nrg2415
- PMCID
- PMC2694620
Sexual dimorphism in anatomical, physiological and behavioural traits are characteristics of many vertebrate species. In humans, sexual dimorphism is also observed in the prevalence, course and severity of many common diseases, including cardiovascular diseases, autoimmune diseases and asthma. Although sex differences in the endocrine and immune systems probably contribute to these observations, recent studies suggest that sex-specific genetic architecture also influences human phenotypes, including reproductive, physiological and disease traits. It is likely that an underlying mechanism is differential gene regulation in males and females, particularly in sex steroid-responsive genes. Genetic studies that ignore sex-specific effects in their design and interpretation could fail to identify a significant proportion of the genes that contribute to risk for complex diseases.
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| Gender issues in cardiovascular diseases. Focus on energy metabolism. | Ventura-Clapier R et al. | β | 2020 | β |
| Genetic polymorphisms of superoxide dismutase 1Β are associated with the serum lipid profiles of Han Chinese adults in a sexually dimorphic manner. | Xu P et al. | β | 2020 | β |
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| Glucocorticoid Sexual Dimorphism in Metabolism: Dissecting the Role of Sex Hormones. | Kroon J et al. | β | 2020 | β |
| GWAS of Post-Orthodontic Aggressive External Apical Root Resorption Identified Multiple Putative Loci at X-Y Chromosomes. | Iber-DΓaz P et al. | β | 2020 | β |
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| Mechanistic Models of Signaling Pathways Reveal the Drug Action Mechanisms behind Gender-Specific Gene Expression for Cancer Treatments. | Γubuk C et al. | β | 2020 | β |
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| Sex Differences in Gene Expression and Regulatory Networks across 29 Human Tissues. | Lopes-Ramos CM et al. | β | 2020 | β |
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| Sexually dimorphic production of interleukin-6 in respiratory disease. | Reddy KD et al. | β | 2020 | β |
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| Commentary: Mendelian randomization and women's health. | Censin JC et al. | β | 2019 | β |
| Differential Sensitivity to IL-12 Drives Sex-Specific Differences in the CD8+ T Cell Response to Infection. | Yee Mon KJ et al. | β | 2019 | β |
| Emerging impacts of biological methylation on genetic information. | Kako K et al. | β | 2019 | β |
| Exome sequencing in patients with chronic central serous chorioretinopathy. | Schellevis RL et al. | β | 2019 | β |
| Gene-by-Sex Interactions in Mitochondrial Functions and Cardio-Metabolic Traits. | Norheim F et al. | β | 2019 | β |
| Genetic parameters of meat quality, carcass composition, and growth traits in commercial swine. | Khanal P et al. | β | 2019 | β |
| Genome-wide analysis revealed sex-specific gene expression in asthmatics. | Gautam Y et al. | β | 2019 | β |
| Identification of female-specific genetic variants for metabolic syndrome and its component traits to improve the prediction of metabolic syndrome in females. | Kong S et al. | β | 2019 | β |
| Inferring the potentially complex genetic architectures of adaptation, sexual dimorphism and genotype by environment interactions by partitioning of mean phenotypes. | Armstrong A et al. | β | 2019 | β |
| KDM5D-mediated H3K4 demethylation is required for sexually dimorphic gene expression in mouse embryonic fibroblasts. | Mizukami H et al. | β | 2019 | β |
| Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratio in Chinese Han population from Chaoshan region in South China. | Wu L et al. | β | 2019 | β |
| Novel Loci Controlling Parasite Load in Organs of Mice Infected With <i>Leishmania major</i>, Their Interactions and Sex Influence. | Kobets T et al. | β | 2019 | β |
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| Putative contributions of the sex chromosome proteins SOX3 and SRY to neurodevelopmental disorders. | Tahira AC et al. | β | 2019 | β |
| Regional gender differences in an autosomal disease result in corresponding diversity differences. | Guan S et al. | β | 2019 | β |
| Sex-Based Analysis of De Novo Variants in Neurodevelopmental Disorders. | Turner TN et al. | β | 2019 | β |
| Sex differences in GBM revealed by analysis of patient imaging, transcriptome, and survival data. | Yang W et al. | β | 2019 | β |
| Sex Differences in Intestinal Carbohydrate Metabolism Promote Food Intake and Sperm Maturation. | Hudry B et al. | β | 2019 | β |
| Sex Differences in Pediatric Rheumatology. | Cattalini M et al. | β | 2019 | β |
| Sex-Related Differences in Impact on Safety of Pharmacogenetic Profile for Colon Cancer Patients Treated with FOLFOX-4 or XELOX Adjuvant Chemotherapy. | Ruzzo A et al. | β | 2019 | β |
| Sex-specific differences in the intracellular proteome of human endothelial cells from dizygotic twins. | Witt E et al. | β | 2019 | β |
| Sexual dimorphism in solid and hematological malignancies. | Ben-Batalla I et al. | β | 2019 | β |
| Sexual dimorphism in the expression of GKN2 and FOXA2 genes in the human stomach. | Mohammadi R et al. | β | 2019 | β |
| Systems genetics applications in metabolism research. | Seldin M et al. | β | 2019 | β |
| The Effect of MPP+ on the Viability of Primary Cortical Astrocytes Isolated from Female and Male Wistar Rats of Different Ages. | AlarcΓ³n-Aguilar A et al. | β | 2019 | β |
| The Number of X Chromosomes Influences Inflammatory Cytokine Production Following Toll-Like Receptor Stimulation. | LefΓ¨vre N et al. | β | 2019 | β |
| The pathobiology of polycystic kidney disease from a metabolic viewpoint. | Menezes LF et al. | β | 2019 | β |
| The placenta as a window to the brain: A review on the role of placental markers in prenatal programming of neurodevelopment. | Shallie PD et al. | β | 2019 | β |
| The route of administration, timing, duration and dose of postmenopausal hormone therapy and cardiovascular outcomes in women: a systematic review. | Oliver-Williams C et al. | β | 2019 | β |
| Tissue-specific sex differences in human gene expression. | Kassam I et al. | β | 2019 | β |
| Wheezing in children: Approaches to diagnosis and management. | Al-Shamrani A et al. | β | 2019 | β |
| Age-related mechanical strength evolution of trabecular bone under fatigue damage for both genders: Fracture risk evaluation. | Ben Kahla R et al. | β | 2018 | β |
| Analysis of Parent-of-Origin Effects on the X Chromosome in Asian and European Orofacial Cleft Triads Identifies Associations with <i>DMD, FGF13, EGFL6</i>, and Additional Loci at Xp22.2. | Skare Γ et al. | β | 2018 | β |
| Antagonistic pleiotropy in species with separate sexes, and the maintenance of genetic variation in life-history traits and fitness. | Zajitschek F et al. | β | 2018 | β |
| Associations of Endogenous Estradiol and Testosterone Levels With Plaque Composition and Risk of Stroke in Subjects With Carotid Atherosclerosis. | Glisic M et al. | β | 2018 | β |
| Associations of gender and serum total cholesterol with CD4+ T cell count and HIV RNA load in antiretroviral-naΓ―ve individuals in Addis Ababa. | Adal M et al. | β | 2018 | β |
| At the Crossroads of Fate-Somatic Cell Lineage Specification in the Fetal Gonad. | Rotgers E et al. | β | 2018 | β |
| A Variant of COL3A1 (rs3134646) Is Associated With Risk of Developing Diverticulosis in White Men. | Reichert MC et al. | β | 2018 | β |
| Development and initial Experience of an online Exchange Platform on Sex and Gender Aspects in Medicine: "GenderMed-Wiki". | SchreitmΓΌller J et al. | β | 2018 | β |
| Effects of Diacetyl Flavoring Exposure in Mice Metabolism. | Jedlicka LDL et al. | β | 2018 | β |
| Genetic Variant rs755622 Regulates Expression of the Multiple Sclerosis Severity Modifier D-Dopachrome Tautomerase in a Sex-Specific Way. | Han Z et al. | β | 2018 | β |
| Global DNA methylation changes spanning puberty are near predicted estrogen-responsive genes and enriched for genes involved in endocrine and immune processes. | Thompson EE et al. | β | 2018 | β |
| Identification and analysis of the human sex-biased genes. | Guo S et al. | β | 2018 | β |
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| Linking local adaptation with the evolution of sex differences. | Connallon T et al. | β | 2018 | β |
| Mapping of quantitative trait loci for temporal growth and age at maturity in coho salmon: Evidence for genotype-by-sex interactions. | Kodama M et al. | β | 2018 | β |
| Opposite Genetic Effects of CMIP Polymorphisms on the Risk of Type 2 Diabetes and Obesity: A Family-Based Study in China. | Cao Y et al. | β | 2018 | β |
| Oxidative Stress as Cause, Consequence, or Biomarker of Altered Female Reproduction and Development in the Space Environment. | Steller JG et al. | β | 2018 | β |
| Precision medicine and drug development in Alzheimer's disease: the importance of sexual dimorphism and patient stratification. | Hampel H et al. | β | 2018 | β |
| Prenatal and pubertal testosterone affect brain lateralization. | Beking T et al. | β | 2018 | β |
| Prepubertal skeletal muscle growth requires Pax7-expressing satellite cell-derived myonuclear contribution. | Bachman JF et al. | β | 2018 | β |
| Pretreatment subcutaneous adipose tissue predicts the outcomes of patients with head and neck cancer receiving definitive radiation and chemoradiation in Taiwan. | Pai PC et al. | β | 2018 | β |
| sEst: Accurate Sex-Estimation and Abnormality Detection in Methylation Microarray Data. | Jung CH et al. | β | 2018 | β |
| Sex- and age patterns in incidence of infectious diseases in Germany: analyses of surveillance records over a 13-year period (2001-2013). | Walter F et al. | β | 2018 | β |
| Sex- and Development-Dependent Responses of Rat Microglia to Pro- and Anti-inflammatory Stimulation. | Lively S et al. | β | 2018 | β |
| Sex: A Significant Risk Factor for Neurodevelopmental and Neurodegenerative Disorders. | Pinares-Garcia P et al. | β | 2018 | β |
| Sex Differences in Genetic Associations With Longevity. | Zeng Y et al. | β | 2018 | β |
| Sex differences in metabolism and cardiometabolic disorders. | Chella Krishnan K et al. | β | 2018 | β |
| Sex-lethal in neurons controls female body growth in Drosophila. | Sawala A et al. | β | 2018 | β |
| The Association of Mid- and Late-Life Systemic Inflammation with Brain Amyloid Deposition: The ARIC-PET Study. | Walker KA et al. | β | 2018 | β |
| The distribution and functional relevance analysis of runs of homozygosity (ROHs) in Chinese Han female population. | Lu YH et al. | β | 2018 | β |
| The PPARG Pro12Ala Polymorphism and 20-year Cognitive Decline: Race and Sex Heterogeneity. | West NA et al. | β | 2018 | β |
| X-Chromosome Inactivation: A Crossroads Between Chromosome Architecture and Gene Regulation. | Galupa R et al. | β | 2018 | β |
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| A hierarchical causal taxonomy of psychopathology across the life span. | Lahey BB et al. | β | 2017 | β |
| Androgen-responsive non-coding small RNAs extend the potential of HCG stimulation to act as a bioassay of androgen sufficiency. | Rodie ME et al. | β | 2017 | β |
| Association of inflammatory bowel disease with ankylosing spondylitis and rheumatoid arthritis: A nationwide population-based study. | Bae JM et al. | β | 2017 | β |
| Association of TNFSF13 polymorphisms with IgA nephropathy in a Chinese Han population. | Zhong Z et al. | β | 2017 | β |
| Associations between gender, disease features and symptom burden in patients with myeloproliferative neoplasms: an analysis by the MPN QOL International Working Group. | Geyer HL et al. | β | 2017 | β |
| Candidate genes have sex-specific effects on timing of spring migration and moult speed in a long-distance migratory bird. | Bazzi G et al. | β | 2017 | β |
| Detecting associated single-nucleotide polymorphisms on the X chromosome in case control genome-wide association studies. | Chen Z et al. | β | 2017 | β |
| Dissecting genetic architecture of startle response in Drosophila melanogaster using multi-omics information. | Xue A et al. | β | 2017 | β |
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| Enhanced heart failure, mortality and renin activation in female mice with experimental dilated cardiomyopathy. | Tripathi R et al. | β | 2017 | β |
| Extracting Country-of-Origin from Electronic Health Records for Gene- Environment Studies as Part of the Epidemiologic Architecture for Genes Linked to Environment (EAGLE) Study. | Farber-Eger E et al. | β | 2017 | β |
| Familial Analysis of Epistatic and Sex-Dependent Association of Genes of the Renin-Angiotensin-Aldosterone System and Blood Pressure. | Scurrah KJ et al. | β | 2017 | β |
| Gender-Specific Association Between FGFR4 Gly388Arg Gene Variants and Hypertension. | Al-Daghri NM et al. | β | 2017 | β |
| Genetic Mechanisms Leading to Sex Differences Across Common Diseases and Anthropometric Traits. | Traglia M et al. | β | 2017 | β |
| Genome-Wide Association Studies of a Broad Spectrum of Antisocial Behavior. | Tielbeek JJ et al. | β | 2017 | β |
| Genome-wide integrative analysis identified SNP-miRNA-mRNA interaction networks in peripheral blood mononuclear cells. | Lin X et al. | β | 2017 | β |
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| Human Y-chromosome variation in the genome-sequencing era. | Jobling MA et al. | β | 2017 | β |
| Improving the Identification of Phenotypic Abnormalities and Sexual Dimorphism in Mice When Studying Rare Event Categorical Characteristics. | Karp NA et al. | β | 2017 | β |
| Isogenic mice exhibit sexually-dimorphic DNA methylation patterns across multiple tissues. | McCormick H et al. | β | 2017 | β |
| Majority of human traits do not show evidence for sex-specific genetic and environmental effects. | Stringer S et al. | β | 2017 | β |
| Male-specific association of the FCGR2A His167Arg polymorphism with Kawasaki disease. | Kwon YC et al. | β | 2017 | β |
| Mitochondria: a central target for sex differences in pathologies. | Ventura-Clapier R et al. | β | 2017 | β |
| Prevalence of sexual dimorphism in mammalian phenotypic traits. | Karp NA et al. | β | 2017 | β |
| Preventing harmful effects of epileptic seizures on cerebrovascular functions in newborn pigs: does sex matter? | Liu J et al. | β | 2017 | β |
| Review: Sexual dimorphism in the formation, function and adaptation of the placenta. | Kalisch-Smith JI et al. | β | 2017 | β |
| Sex-Based Genetic Association Study Identifies CELSR1 as a Possible Chronic Obstructive Pulmonary Disease Risk Locus among Women. | Hardin M et al. | β | 2017 | β |
| Sex-Dependent Intestinal Replication of an Enteric Virus. | Robinson CM et al. | β | 2017 | β |
| Sex differences in microRNA-mRNA networks: examination of novel epigenetic programming mechanisms in the sexually dimorphic neonatal hypothalamus. | Morgan CP et al. | β | 2017 | β |
| Sex differences in the molecular signature of the developing mouse hippocampus. | Bundy JL et al. | β | 2017 | β |
| Sex disparities in cancer incidence in Jiashan County, China, 1995-2014. | Jiang X et al. | β | 2017 | β |
| Sex-specific differences in transcriptome profiles of brain and muscle tissue of the tropical gar. | Cribbin KM et al. | β | 2017 | β |
| Sex-specific effect of RNASEL rs486907 and miR-146a rs2910164 polymorphisms' interaction as a susceptibility factor for melanoma skin cancer. | Sangalli A et al. | β | 2017 | β |
| Sex-Specific Genetic Risk Factors for Chronic Obstructive Pulmonary Disease. | Brusselle GG et al. | β | 2017 | β |
| Sexual dimorphisms in genetic loci linked to body fat distribution. | Pulit SL et al. | β | 2017 | β |
| The Gut Microbiota of Healthy Aged Chinese Is Similar to That of the Healthy Young. | Bian G et al. | β | 2017 | β |
| The stability of the transcriptome during the estrous cycle in four regions of the mouse brain. | DiCarlo LM et al. | β | 2017 | β |
| The transcriptional architecture of phenotypic dimorphism. | Mank JE | β | 2017 | β |
| Urinary sexual steroids associated with bisphenol A (BPA) exposure in the early infant stage: Preliminary results from a Daishan birth cohort. | Wang H et al. | β | 2017 | β |
| Y Chromosome, Mitochondrial DNA and Childhood Behavioural Traits. | Howe LJ et al. | β | 2017 | β |
| Autosomal genetic control of human gene expression does not differ across the sexes. | Kassam I et al. | β | 2016 | β |
| Bias in the reporting of sex and age in biomedical research on mouse models. | FlΓ³rez-Vargas O et al. | β | 2016 | β |
| Comprehensive and quantitative proteomic analyses of zebrafish plasma reveals conserved protein profiles between genders and between zebrafish and human. | Li C et al. | β | 2016 | β |
| Developmental evidence for obstetric adaptation of the human female pelvis. | Huseynov A et al. | β | 2016 | β |
| Difference in Leukocyte Composition between Women before and after Menopausal Age, and Distinct Sexual Dimorphism. | Chen Y et al. | β | 2016 | β |
| ESR1 polymorphisms and statin therapy: a sex-specific approach. | Smiderle L et al. | β | 2016 | β |
| Evidence for sex-specific genetic architectures across a spectrum of human complex traits. | Rawlik K et al. | β | 2016 | β |
| FARVATX: Family-Based Rare Variant Association Test for X-Linked Genes. | Choi S et al. | β | 2016 | β |
| Gene-specific sex effects on eosinophil infiltration in leishmaniasis. | SlapniΔkovΓ‘ M et al. | β | 2016 | β |
| Identification of Susceptibility Genes of Adult Asthma in French Canadian Women. | BΓ©rubΓ© JC et al. | β | 2016 | β |
| Immune Regulation in Pregnancy: A Matter of Perspective? | Bonney EA | β | 2016 | β |
| Impact of the X Chromosome and sex on regulatory variation. | Kukurba KR et al. | β | 2016 | β |
| Leveraging gene-environment interactions and endotypes for asthma gene discovery. | BΓΈnnelykke K et al. | β | 2016 | β |
| Non-negligible Occurrence of Errors in Gender Description in Public Data Sets. | Kim JH et al. | β | 2016 | β |
| Prevalence of colonic diverticulosis in mainland China from 2004 to 2014. | Hong W et al. | β | 2016 | β |
| Protein S-Glutathionylation Mediates Macrophage Responses to Metabolic Cues from the Extracellular Environment. | Ullevig SL et al. | β | 2016 | β |
| RhoA/ROCK signaling contributes to sex differences in the activation of human platelets. | Schubert P et al. | β | 2016 | β |
| Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus. | Kautzky-Willer A et al. | β | 2016 | β |
| Sex bias in paediatric autoimmune disease - Not just about sex hormones? | Chiaroni-Clarke RC et al. | β | 2016 | β |
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| Sex hormones establish a reserve pool of adult muscle stem cells. | Kim JH et al. | β | 2016 | β |
| Sex-Specific Protection of Osteoarthritis by Deleting Cartilage Acid Protein 1. | Ge X et al. | β | 2016 | β |
| Sexual Dimorphism: How Female Cells Win the Race. | Deng H et al. | β | 2016 | β |
| Sexual dimorphism in the mast cell transcriptome and the pathophysiological responses to immunological and psychological stress. | Mackey E et al. | β | 2016 | β |
| The Association of Mitofusion-2 Gene Polymorphisms with Susceptibility of Essential Hypertension in Northern Han Chinese Population. | Li M et al. | β | 2016 | β |
| The autosomal genetic control of sexually dimorphic traits in humans is largely the same across the sexes. | Kassam I et al. | β | 2016 | β |
| The genetics of pubertal timing in the general population: recent advances and evidence for sex-specificity. | Cousminer DL et al. | β | 2016 | β |
| The phenotypic impact of the male-specific region of chromosome-Y in inbred mating: the role of genetic variants and gene duplications in multiple inbred rat strains. | Prokop JW et al. | β | 2016 | β |
| The sexual identity of adult intestinal stem cells controls organ size and plasticity. | Hudry B et al. | β | 2016 | β |
| Transcriptomic analysis of the hippocampus from six inbred strains of mice suggests a basis for sex-specific susceptibility and severity of neurological disorders. | Vied C et al. | β | 2016 | β |
| Why we should consider sex (and study sex differences) in addiction research. | Sanchis-Segura C et al. | β | 2016 | β |
| A common risk variant in CACNA1C supports a sex-dependent effect on longitudinal functioning and functional recovery from episodes of schizophrenia-spectrum but not bipolar disorder. | Heilbronner U et al. | β | 2015 | β |
| Additive transcriptomic variation associated with reproductive traits suggest local adaptation in a recently settled population of the Pacific oyster, Crassostrea gigas. | Sussarellu R et al. | β | 2015 | β |
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| Associations of prodynorphin sequence variation with alcohol dependence and related traits are phenotype-specific and sex-dependent. | Winham SJ et al. | β | 2015 | β |
| Chromosome Y genetic variants: impact in animal models and on human disease. | Prokop JW et al. | β | 2015 | β |
| Effects of interaction between genetic variants in human leukocyte antigen DQ and granulysin genes in Chinese Han subjects infected with hepatitis B virus. | Hou SH et al. | β | 2015 | β |
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| Finding the most appropriate mouse model of juvenile CLN3 (Batten) disease for therapeutic studies: the importance of genetic background and gender. | KovΓ‘cs AD et al. | β | 2015 | β |
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| Genetic architecture of white matter hyperintensities differs in hypertensive and nonhypertensive ischemic stroke. | Adib-Samii P et al. | β | 2015 | β |
| Genetic dissection of the Mss4 locus mediating sex-biased cancer resistance in the rat peripheral nervous system. | van den Berg L et al. | β | 2015 | β |
| Genetic studies of schizophrenia: an update. | Chen J et al. | β | 2015 | β |
| Genome-wide association meta-analyses to identify common genetic variants associated with hallux valgus in Caucasian and African Americans. | Hsu YH et al. | β | 2015 | β |
| Genome-wide genetic homogeneity between sexes and populations for human height and body mass index. | Yang J et al. | β | 2015 | β |
| Genomic architecture of asthma differs by sex. | Mersha TB et al. | β | 2015 | β |
| Genomic conflicts and sexual antagonism in human health: insights from oxytocin and testosterone. | Mokkonen M et al. | β | 2015 | β |
| Hypertension overrides the protective effect of female hormones on the development of aortic aneurysm secondary to Alk5 deficiency via ERK activation. | Schmit BM et al. | β | 2015 | β |
| Integrative analysis of methylome and transcriptome in human blood identifies extensive sex- and immune cell-specific differentially methylated regions. | Mamrut S et al. | β | 2015 | β |
| Intrinsic excitability varies by sex in prepubertal striatal medium spiny neurons. | Dorris DM et al. | β | 2015 | β |
| Microbial endocrinology: the interplay between the microbiota and the endocrine system. | Neuman H et al. | β | 2015 | β |
| Mutations of protocadherin 19 in female epilepsy (PCDH19-FE) lead to allopregnanolone deficiency. | Tan C et al. | β | 2015 | β |
| NeuroTransDB: highly curated and structured transcriptomic metadata for neurodegenerative diseases. | Bagewadi S et al. | β | 2015 | β |
| Positive Association between APOA5 rs662799 Polymorphism and Coronary Heart Disease: A Case-Control Study and Meta-Analysis. | Ye H et al. | β | 2015 | β |
| Probability and heritability estimates on primary osteoarthritis of the hip leading to total hip arthroplasty: a nationwide population based follow-up study in Danish twins. | Skousgaard SG et al. | β | 2015 | β |
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| Roles of the Y chromosome genes in human cancers. | Kido T et al. | β | 2015 | β |
| Sex Differences in Antiretroviral Therapy Initiation in Pediatric HIV Infection. | Mori M et al. | β | 2015 | β |
| Sex-specific association of rs4746172 of VCL gene with hypertension in two Han populations from Southern China. | Yu Q et al. | β | 2015 | β |
| Sexually dimorphic gene expression emerges with embryonic genome activation and is dynamic throughout development. | Lowe R et al. | β | 2015 | β |
| Similarities and differences of X and Y chromosome homologous genes, SRY and SOX3, in regulating the renin-angiotensin system promoters. | Araujo FC et al. | β | 2015 | β |
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| The association of PTPN22 rs2476601 with juvenile idiopathic arthritis is specific to females. | Chiaroni-Clarke RC et al. | β | 2015 | β |
| The cyclic AMP pathway is a sex-specific modifier of glioma risk in type I neurofibromatosis patients. | Warrington NM et al. | β | 2015 | β |
| The evolution of sex differences in disease. | Morrow EH | β | 2015 | β |
| THE GENETICS OF EPIGENETIC INHERITANCE: MODES, MOLECULES, AND MECHANISMS. | Schaefer S et al. | β | 2015 | β |
| The human sex ratio from conception to birth. | Orzack SH et al. | β | 2015 | β |
| The role of apolipoprotein E episilon (Ξ΅)-4 allele on outcome following traumatic brain injury: A systematic review. | Lawrence DW et al. | β | 2015 | β |
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| Antioxidant defense enzyme genes and asthma susceptibility: gender-specific effects and heterogeneity in gene-gene interactions between pathogenetic variants of the disease. | Polonikov AV et al. | β | 2014 | β |
| A scoring strategy combining statistics and functional genomics supports a possible role for common polygenic variation in autism. | Carayol J et al. | β | 2014 | β |
| Association of CDKN2BAS polymorphism rs4977574 with coronary heart disease: a case-control study and a meta-analysis. | Huang Y et al. | β | 2014 | β |
| Association of CRP gene polymorphisms with serum CRP level and handgrip strength in community-dwelling elders in Taiwan: Taichung Community Health Study for Elders (TCHS-E). | Lin CC et al. | β | 2014 | β |
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| Coronary artery disease predisposing haplogroup I of the Y chromosome, aggression and sex steroids--genetic association analysis. | Bloomer LD et al. | β | 2014 | β |
| Development and evaluation of 'briefing notes' as a novel knowledge translation tool to aid the implementation of sex/gender analysis in systematic reviews: a pilot study. | Doull M et al. | β | 2014 | β |
| Evaluation of sexual dimorphism in the efficacy and safety of simvastatin/atorvastatin therapy in a southern Brazilian cohort. | Smiderle L et al. | β | 2014 | β |
| Frequent and sex-biased deletion of SLX4IP by illegitimate V(D)J-mediated recombination in childhood acute lymphoblastic leukemia. | Meissner B et al. | β | 2014 | β |
| Genome-wide interaction studies reveal sex-specific asthma risk alleles. | Myers RA et al. | β | 2014 | β |
| Human placental transcriptome shows sexually dimorphic gene expression and responsiveness to maternal dietary n-3 long-chain polyunsaturated fatty acid intervention during pregnancy. | Sedlmeier EM et al. | β | 2014 | β |
| Imprinted and X-linked non-coding RNAs as potential regulators of human placental function. | Buckberry S et al. | β | 2014 | β |
| Influence of sex steroids on inflammation and bone metabolism. | Shiau HJ et al. | β | 2014 | β |
| Lipidomic analysis of serum from high fat diet induced obese mice. | Eisinger K et al. | β | 2014 | β |
| massiR: a method for predicting the sex of samples in gene expression microarray datasets. | Buckberry S et al. | β | 2014 | β |
| Microbiome manipulation modifies sex-specific risk for autoimmunity. | Markle JG et al. | β | 2014 | β |
| Modifiable risk factors in periodontitis: at the intersection of aging and disease. | Reynolds MA | β | 2014 | β |
| Peri-conceptional obesogenic exposure induces sex-specific programming of disease susceptibilities in adult mouse offspring. | Dahlhoff M et al. | β | 2014 | β |
| Reduced selection and accumulation of deleterious mutations in genes exclusively expressed in men. | Gershoni M et al. | β | 2014 | β |
| RTeQTL: Real-Time Online Engine for Expression Quantitative Trait Loci Analyses. | Ma B et al. | β | 2014 | β |
| Sex- and age-interacting eQTLs in human complex diseases. | Yao C et al. | β | 2014 | β |
| Sex and gender differences in the causes of dementia: a narrative review. | Rocca WA et al. | β | 2014 | β |
| Sex-dependent genetic effects on immune responses to a parasitic nematode. | Hayes KS et al. | β | 2014 | β |
| Sex differences in disease genetics: evidence, evolution, and detection. | Gilks WP et al. | β | 2014 | β |
| Sex differences in pediatric infectious diseases. | Muenchhoff M et al. | β | 2014 | β |
| Sex differences in the human peripheral blood transcriptome. | Jansen R et al. | β | 2014 | β |
| Sex matters for mechanism. | Danska JS | β | 2014 | β |
| Sex-specific association of the peptidase D gene rs731839 polymorphism and serum lipid levels in the Mulao and Han populations. | Lin QZ et al. | β | 2014 | β |
| Sexual dimorphism in tuberculosis incidence: children cases compared to adult cases in Tuscany from 1997 to 2011. | Stival A et al. | β | 2014 | β |
| Sexually dimorphic genetic architecture of complex traits in a large-scale F2 cross in pigs. | Cui L et al. | β | 2014 | β |
| Sexually dimorphic RB inactivation underlies mesenchymal glioblastoma prevalence in males. | Sun T et al. | β | 2014 | β |
| Single nucleotide variations: biological impact and theoretical interpretation. | Katsonis P et al. | β | 2014 | β |
| SLC30A8 nonsynonymous variant is associated with recovery following exercise and skeletal muscle size and strength. | Sprouse C et al. | β | 2014 | β |
| Small MAF genes variants and chronic myeloid leukemia. | MartΓnez-HernΓ‘ndez A et al. | β | 2014 | β |
| The challenges of including sex/gender analysis in systematic reviews: a qualitative survey. | Runnels V et al. | β | 2014 | β |
| The sex bias in systemic sclerosis: on the possible mechanisms underlying the female disease preponderance. | D'Amico F et al. | β | 2014 | β |
| Whole exome sequencing of a dominant retinitis pigmentosa family identifies a novel deletion in PRPF31. | Villanueva A et al. | β | 2014 | β |
| Why are sex and gender important to basic physiology and translational and individualized medicine? | Miller VM | β | 2014 | β |
| X marks the spot: does it matter that O-GlcNAc transferase is an X-linked gene? | Olivier-Van Stichelen S et al. | β | 2014 | β |
| Adrenal tumours are more predominant in females regardless of their histological subtype: a review. | Audenet F et al. | β | 2013 | β |
| Androgen receptor function links human sexual dimorphism to DNA methylation. | Ammerpohl O et al. | β | 2013 | β |
| An emerging role for microRNAs in sexually dimorphic neurobiological systems. | Pak TR et al. | β | 2013 | β |
| An X chromosome-wide association analysis identifies variants in GPR174 as a risk factor for Graves' disease. | Chu X et al. | β | 2013 | β |
| Assessment of gender distribution in dengue surveillance data, the Lao People's Democratic Republic. | Prasith N et al. | β | 2013 | β |
| Contribution of CD4+ T cells and dendritic cells to female-dominant antigen-induced T helper type 2 cytokine production by bronchial lymph node cells. | Okuyama K et al. | β | 2013 | β |
| Elevated expression of H19 and Igf2 in the female mouse eye. | Reinius B et al. | β | 2013 | β |
| Estradiol downregulates NF-ΞΊb translocation by Ikbkg transcriptional repression in dendritic cells. | Lasarte S et al. | β | 2013 | β |
| Gender differences in chronic pruritus: women present different morbidity, more scratch lesions and higher burden. | StΓ€nder S et al. | β | 2013 | β |
| Gender-specific gene-environment interaction in alcohol dependence: the impact of daily life events and GABRA2. | Perry BL et al. | β | 2013 | β |
| Glutamatergic GRIN2B and polyaminergic ODC1 genes in suicide attempts: associations and gene-environment interactions with childhood/adolescent physical assault. | Sokolowski M et al. | β | 2013 | β |
| Heritability of life span is largely sex limited in Drosophila. | Lehtovaara A et al. | β | 2013 | β |
| Implications of sex-specific selection for the genetic basis of disease. | Morrow EH et al. | β | 2013 | β |
| Inverted expression profiles of sex-biased genes in response to toxicant perturbations and diseases. | Ung CY et al. | β | 2013 | β |
| Location- and sex-specific differences in weight and motor coordination in two commonly used mouse strains. | KovΓ‘cs AD et al. | β | 2013 | β |
| Male-biased autosomal effect of 16p13.11 copy number variation in neurodevelopmental disorders. | Tropeano M et al. | β | 2013 | β |
| Maternal microchimerism protects against the development of asthma. | Thompson EE et al. | β | 2013 | β |
| Novel effects of chromosome Y on cardiac regulation, chromatin remodeling, and neonatal programming in male mice. | Praktiknjo SD et al. | β | 2013 | β |
| O-GlcNAc transferase (OGT) as a placental biomarker of maternal stress and reprogramming of CNS gene transcription in development. | Howerton CL et al. | β | 2013 | β |
| Placental contribution to the origins of sexual dimorphism in health and diseases: sex chromosomes and epigenetics. | Gabory A et al. | β | 2013 | β |
| Positive association between rs10918859 of the NOS1AP gene and coronary heart disease in male Han Chinese. | Huang Y et al. | β | 2013 | β |
| PPARA, RXRA, NR1I2 and NR1I3 gene polymorphisms and lipid and lipoprotein levels in a Southern Brazilian population. | Lima LO et al. | β | 2013 | β |
| Relationship between chemokine (C-X-C motif) ligand 12 gene variant (rs1746048) and coronary heart disease: case-control study and meta-analysis. | Huang Y et al. | β | 2013 | β |
| Sex bias in infectious disease epidemiology: patterns and processes. | Guerra-Silveira F et al. | β | 2013 | β |
| Sex differences in risk factors for coronary artery disease and stroke in men and women aged 45-65β years. | Hochner-Celnikier D et al. | β | 2013 | β |
| Sex differences in the expression of lupus-associated miRNAs in splenocytes from lupus-prone NZB/WF1 mice. | Dai R et al. | β | 2013 | β |
| Sex differences in the gut microbiome drive hormone-dependent regulation of autoimmunity. | Markle JG et al. | β | 2013 | β |
| Sex disparities in cancer mortality: the risks of being a man in the United States. | Najari BB et al. | β | 2013 | β |
| Sex-specific associations of variants in regulatory regions of NADPH oxidase-2 (CYBB) and glutathione peroxidase 4 (GPX4) genes with kidney disease in type 1 diabetes. | Monteiro MB et al. | β | 2013 | β |
| Sex-specific interactions between the IRS1 polymorphism and intakes of carbohydrates and fat on incident type 2 diabetes. | Ericson U et al. | β | 2013 | β |
| Social environment influences the relationship between genotype and gene expression in wild baboons. | Runcie DE et al. | β | 2013 | β |
| The psychiatric vulnerability gene CACNA1C and its sex-specific relationship with personality traits, resilience factors and depressive symptoms in the general population. | Strohmaier J et al. | β | 2013 | β |
| The Y chromosome as a regulatory element shaping immune cell transcriptomes and susceptibility to autoimmune disease. | Case LK et al. | β | 2013 | β |
| Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease. | Cooper DN et al. | β | 2013 | β |
| Widespread sex differences in gene expression and splicing in the adult human brain. | Trabzuni D et al. | β | 2013 | β |
| Analysis of a genome-wide association study-linked locus (CCR6) in Asian rheumatoid arthritis. | Teng E et al. | β | 2012 | β |
| Assessment of gene-by-sex interaction effect on bone mineral density. | Liu CT et al. | β | 2012 | β |
| Cardiovascular phenotype in Turner syndrome--integrating cardiology, genetics, and endocrinology. | Mortensen KH et al. | β | 2012 | β |
| Clinical review: Genome-wide association studies of skeletal phenotypes: what we have learned and where we are headed. | Hsu YH et al. | β | 2012 | β |
| Considerations of sex and gender differences in preclinical and clinical trials. | Raz L et al. | β | 2012 | β |
| Gender differences in cancer susceptibility: an inadequately addressed issue. | Dorak MT et al. | β | 2012 | β |
| Genetic polymorphisms in estrogen receptors and sexual dimorphism in fat redistribution in HIV-infected patients on HAART. | Gasparotto AS et al. | β | 2012 | β |
| In pursuit of scientific excellence: sex matters. | Miller VM | β | 2012 | β |
| In pursuit of scientific excellence: sex matters. | Miller VM | β | 2012 | β |
| In pursuit of scientific excellence: sex matters. | Miller VM | β | 2012 | β |
| In pursuit of scientific excellence: sex matters. | Miller VM | β | 2012 | β |
| In pursuit of scientific excellence: sex matters. | Miller VM | β | 2012 | β |
| In pursuit of scientific excellence: sex matters. | Miller VM | β | 2012 | β |
| In pursuit of scientific excellence: sex matters. | Miller VM | β | 2012 | β |
| In pursuit of scientific excellence: sex matters. | Miller VM | β | 2012 | β |
| In pursuit of scientific excellence: sex matters. | Miller VM | β | 2012 | β |
| In pursuit of scientific excellence: sex matters. | Miller VM | β | 2012 | β |
| Particular characteristics of allergic symptoms in tropical environments: follow up to 24 months in the FRAAT birth cohort study. | Acevedo N et al. | β | 2012 | β |
| Physical activity and sex modulate obesity risk linked to 3111T/C gene variant of the CLOCK gene in an elderly population: the SUN Project. | Galbete C et al. | β | 2012 | β |
| Progesterone and autoimmune disease. | Hughes GC | β | 2012 | β |
| Sex-biased genetic effects on gene regulation in humans. | Dimas AS et al. | β | 2012 | β |
| Sex differences in disease risk from reported genome-wide association study findings. | Liu LY et al. | β | 2012 | β |
| Sex differences in inflammatory cytokines and CD99 expression following in vitro lipopolysaccharide stimulation. | LefΓ¨vre N et al. | β | 2012 | β |
| Sex differences in microRNA regulation of gene expression: no smoke, just miRs. | Morgan CP et al. | β | 2012 | β |
| Sex, gender and emerging infectious disease surveillance: a leptospirosis case study. | Skufca J et al. | β | 2012 | β |
| Sex-specific differences in effect size estimates at established complex trait loci. | Orozco G et al. | β | 2012 | β |
| Sex-specific modulation of gene expression networks in murine hypothalamus. | Mozhui K et al. | β | 2012 | β |
| The genetic architecture of a complex ecological trait: host plant use in the specialist moth, Heliothis subflexa. | Oppenheim SJ et al. | β | 2012 | β |
| The influence of sex and gender on the immune response. | Oertelt-Prigione S | β | 2012 | β |
| The sex-specific association of Met62Ile gene polymorphism in P-selectin glycoprotein ligand (PSGL-1) with carotid plaque presence: preliminary study. | ZivkoviΔ M et al. | β | 2012 | β |
| Transmission distortion in Crohn's disease risk gene ATG16L1 leads to sex difference in disease association. | Liu LY et al. | β | 2012 | β |
| Understanding the sexome: measuring and reporting sex differences in gene systems. | Arnold AP et al. | β | 2012 | β |
| What a difference an X or Y makes: sex chromosomes, gene dose, and epigenetics in sexual differentiation. | Arnold AP et al. | β | 2012 | β |
| Cognitive effects of genetic variation in monoamine neurotransmitter systems: a population-based study of COMT, MAOA, and 5HTTLPR. | Barnett JH et al. | β | 2011 | β |
| DNA methylation patterns associate with genetic and gene expression variation in HapMap cell lines. | Bell JT et al. | β | 2011 | β |
| Epigenetic regulation of autosomal gene expression by sex chromosomes. | Wijchers PJ et al. | β | 2011 | β |
| Gene-environment interactions in human disease: nuisance or opportunity? | Ober C et al. | β | 2011 | β |
| IFNG genotype and sex interact to influence the risk of childhood asthma. | Loisel DA et al. | β | 2011 | β |
| Interference of kallikrein 1b26 (klk1b26) translation by microRNA specifically expressed in female mouse submandibular glands: an additional mechanism for sexual dimorphism of klk1b26 protein in the glands. | Kurihara K et al. | β | 2011 | β |
| Methods for detecting interactions between imprinted genes and environmental exposures using birth cohort designs with mother-offspring pairs. | Wang S et al. | β | 2011 | β |
| RELN rs7341475 and schizophrenia risk: confusing, yet somehow intriguing. | Tost H et al. | β | 2011 | β |
| Reporting of sex as a variable in cardiovascular studies using cultured cells. | Taylor KE et al. | β | 2011 | β |
| Sex-biased suppression of chemically induced neural carcinogenesis in congenic BDIX.BDIV-Mss4a rats. | Koelsch B et al. | β | 2011 | β |
| Sex differences in HIV RNA level and CD4 cell percentage during childhood. | Ruel TD et al. | β | 2011 | β |
| Sex disparities in cancer mortality and survival. | Cook MB et al. | β | 2011 | β |
| The future of model organisms in human disease research. | Aitman TJ et al. | β | 2011 | β |
| The genetics of asthma and allergic disease: a 21st century perspective. | Ober C et al. | β | 2011 | β |
| The resolution of sexual antagonism by gene duplication. | Connallon T et al. | β | 2011 | β |
| Transcriptional profiling of human liver identifies sex-biased genes associated with polygenic dyslipidemia and coronary artery disease. | Zhang Y et al. | β | 2011 | β |
| Transcriptional sexual dimorphism during preimplantation embryo development and its consequences for developmental competence and adult health and disease. | Bermejo-Alvarez P et al. | β | 2011 | β |
| Transcriptional sexual dimorphism in elongating bovine embryos: implications for XCI and sex determination genes. | Bermejo-Alvarez P et al. | β | 2011 | β |
| X chromosome association testing in genome wide association studies. | Hickey PF et al. | β | 2011 | β |
| Alternatively activated macrophages as cause or effect in airway disease. | Byers DE et al. | β | 2010 | β |
| Commonly studied polymorphisms in inflammatory cytokine genes show only minor effects on mortality and related risk factors in nonagenarians. | Dato S et al. | β | 2010 | β |
| Dioecious Silene latifolia plants show sexual dimorphism in the vegetative stage. | Zluvova J et al. | β | 2010 | β |
| Female-biased expression of long non-coding RNAs in domains that escape X-inactivation in mouse. | Reinius B et al. | β | 2010 | β |
| Five year time course of celiac disease serology during gluten free diet: results of a community based "CD-Watch" program. | Zanini B et al. | β | 2010 | β |
| Gender aspects in skin diseases. | Chen W et al. | β | 2010 | β |
| Gene variations in the cholecystokinin system in patients with panic disorder. | Koefoed P et al. | β | 2010 | β |
| Is the urea cycle involved in Alzheimer's disease? | Hansmannel F et al. | β | 2010 | β |
| Meta-analysis of sex-specific genome-wide association studies. | Magi R et al. | β | 2010 | β |
| Multiple Functional Variants in cis Modulate PDYN Expression. | Babbitt CC et al. | β | 2010 | β |
| No effect of a common allelic variant in the reelin gene on intermediate phenotype measures of brain structure, brain function, and gene expression. | Tost H et al. | β | 2010 | β |
| Sex differences in destructive periodontal disease: a systematic review. | Shiau HJ et al. | β | 2010 | β |
| Sex differences in destructive periodontal disease: exploring the biologic basis. | Shiau HJ et al. | β | 2010 | β |
| Sex differences in molecular neuroscience: from fruit flies to humans. | Jazin E et al. | β | 2010 | β |
| Sex differences in the adolescent brain. | Lenroot RK et al. | β | 2010 | β |
| Sexual dimorphic evolution of metabolic programming in non-genetic non-alimentary mild metabolic syndrome model in mice depends on feed-back mechanisms integrity for pro-opiomelanocortin-derived endogenous substances. | Loizzo S et al. | β | 2010 | β |
| Sexual dimorphism in mammalian autosomal gene regulation is determined not only by Sry but by sex chromosome complement as well. | Wijchers PJ et al. | β | 2010 | β |
| Signatures of natural selection and coevolution between killer cell immunoglobulin-like receptors (KIR) and HLA class I genes. | Guinan KJ et al. | β | 2010 | β |
| The DM domain transcription factor MAB-3 regulates male hypersensitivity to oxidative stress in Caenorhabditis elegans. | Inoue H et al. | β | 2010 | β |
| The pituitary-thyroid axis set point in women is uninfluenced by X chromosome inactivation pattern? A twin study. | Brix TH et al. | β | 2010 | β |
| Two-dimensional, sex-specific autosomal linkage scan of the number of sodium pump sites. | Hasstedt SJ et al. | β | 2010 | β |
| Complete recovery of intestinal mucosa occurs very rarely in adult coeliac patients despite adherence to gluten-free diet. | Lanzini A et al. | β | 2009 | β |
| Disorders of sex development expose transcriptional autonomy of genetic sex and androgen-programmed hormonal sex in human blood leukocytes. | Holterhus PM et al. | β | 2009 | β |
| Gender differences in adult congenital heart disease. | Engelfriet P et al. | β | 2009 | β |
| Gene-environmental interaction in the development of atopic asthma: new developments. | Le SouΓ«f PN | β | 2009 | β |
| Genetic basis of sex-specific resistance to neuro-oncogenesis in (BDIX x BDIV) F(2) rats. | Winzen B et al. | β | 2009 | β |
| Insulin signaling regulating genes: effect on T2DM and cardiovascular risk. | Prudente S et al. | β | 2009 | β |
| Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males. | Liu YZ et al. | β | 2009 | β |
| Sex disparities in cancer incidence by period and age. | Cook MB et al. | β | 2009 | β |
| Sexual dimorphism: Is it relevant to steroid resistance or asthma control? | Hunninghake GM et al. | β | 2009 | β |
| Sexual inequality in tuberculosis. | Neyrolles O et al. | β | 2009 | β |
| Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis. | Hewagama A et al. | β | 2009 | β |
| Systemic correction of storage disease in MPS I NOD/SCID mice using the sleeping beauty transposon system. | Aronovich EL et al. | β | 2009 | β |
| Systems biology asks new questions about sex differences. | Arnold AP et al. | β | 2009 | β |
| The genetics of quantitative traits: challenges and prospects. | Mackay TF et al. | β | 2009 | β |
| The ontogeny of cross-sex genetic correlations: an analysis of patterns. | Poissant J et al. | β | 2009 | β |
| X chromosomal variation is associated with slow progression to AIDS in HIV-1-infected women. | Siddiqui RA et al. | β | 2009 | β |
| X Chromosome inactivation pattern is not associated with interindividual variations in thyroid volume: a study of euthyroid Danish female twins. | Brix TH et al. | β | 2009 | β |
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