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Chunk #12 — Evidence of Sex-Specific Genetic Architecture in Humans — Sex-specific genetic architecture of human quantitative traits: a case study

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Sex-specific genetic architecture of human disease.
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In this population, sex was a significant predictor of the trait value in a linear regression model for 16 of the 19 phenotypes, including cardiovascular disease-associated traits (HDL cholesterol, lipoprotein[a], triglycerides, diastolic and systolic blood pressure), asthma-associated traits (forced expiratory flow at 1 second, (FEV1], the ratio of FEV1 to forced vital capacity [FVC], eosinophil count, total serum IgE level, percent lymphocytes), anthropometrics (body mass index, percent fat, fat free mass, adult height), and signaling molecules (morning serum cortisol, whole blood serotonin). Sex was not a significant predictor of three phenotypes (LDL cholesterol, lymphocyte count, fasting insulin).