To replicate the results of the ADHD GWAS meta-analysis we compared the results to analyses of cohorts from deCODE and 23andMe, and a meta-analysis of two independent studies conducted by EAGLE and QIMR (referred to as EAGLE/QIMR). We evaluated evidence for replication based on: (a) sign tests of concordance between the ADHD GWAS meta-analysis and each replication cohort; (b) comparison of bias-corrected effect sizes between the ADHD GWAS and the deCODE and 23andMe replication cohorts; (c) genetic correlation between the ADHD GWAS and the 23andMe and EAGLE/QIMR replication cohorts; (d) meta-analysis of the ADHD GWAS meta-analysis results with the results from each replication cohort; and (e) tests of heterogeneity between the ADHD GWAS and each replication cohorts.
