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Chunk #7 — Methods — Human Post-mortem Subjects

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Transcriptome alterations are enriched for synapse-associated genes in the striatum of subjects with obsessive-compulsive disorder.
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(PMI; SED = 3.18), and tissue pH (SED = 0.076). The age of unaffected comparison subjects ranged from 20 to 65 years, while the age of OCD subjects ranged from 20 to 69 years (Table 1).Table 1Cohort demographics.OCD subjectsUnaffected comparison subjectsdftpmeanSDnmeanSDnAge (years)47.414.70747.613.428130.030.98pH6.70.1576.60.148131.570.14Post mortem interval (PMI; hours)17.88.37715.24.438130.750.46RNA ratio (260 nm/280 nm)1.60.2471.50.318130.700.49RNA integrity number (RIN)7.80.4477.60.658130.460.65OCD obsessive compulsive disorder, PMI post-mortem interval, RIN RNA integrity number, SD standard deviation, n count, df degrees of freedom, t Student’s t-statistic, p probability.