The curation team has worked particularly hard over the last three years to generate 1057 drug mechanism-of-action (MOA) pathways using the PathWhiz pathway drawing system (8). These new pathways are of much higher quality (in terms of content and detail) than previous pathways, and are also more aesthetically pleasing. To generate these pathways, drugs were classified based on known interactions contained within DrugBank and then further reviewed via additional searches in PubMed (9). In most MOA pathways, information relating to the known route of administration and corresponding path the drug takes to reach the intended site of action are included. Most MOA pathways show direct interactions between the drugs, their receptors, the affected cells, relevant organs and organelles. Detailed text descriptions for each pathway have also been added along with citations. Currently, 1706 approved small molecule and biologic drugs in DrugBank lack well-defined or confirmed drug–target actions (inducer/inhibitor/agonist/etc.); as such, these drugs do not have MOA pathways.
