The curation team also generated 2721 drug metabolism (ADME) pathways based on existing (manually curated) DrugBank drug metabolism data. These pathways are intended to cover the entire journey of each drug from ingestion, distribution to the site of metabolism, the metabolic reactions the drug undergoes and finally culminating in drug/metabolite excretion. Data for the manually generated ADME pathways was gathered via the information contained in DrugBank's extensive (manually annotated) drug metabolism datasets. The ADME pathway was then manually rendered using the same SOPs as with the MOA pathways, including depictions of the organs, organelles, the metabolic reactions as well as a clear indication of how the drug and metabolites are excreted. ADME pathways showing the degradation of DrugBank's protein or nucleic acid (biotech) drugs to individual nucleotides or amino acids have also been added for all biotech drugs.
