IMPUTE221, and the 1000 Genomes Project Phase 3 reference panel, which includes five continental groups19. High-quality imputed SNPs were retained for the association analysis, filtering for imputation INFO score > 0.8 and minor allele frequency (MAF) > 0.01 before analysis. After imputation, we tested for duplicated samples and cryptic relatedness among the cohorts analyzed. The association analysis was conducted considering variants present in at least 80% of the cohorts investigated (Supplementary Table 2).
