The discovery sample differed from the target sample in several important respects. MVP is a study of older adult veterans, predominantly male. The COGA sample is mixed male and female adolescents and young adults and is a sample of subjects at risk for AUD. Perhaps one consequence of this is the observation that PRS for MVP AUD was less effective in the COGA sample than PRS for MAX_ALC; types of AUD diagnoses in the two samples may differ more than this quantitative lifetime measure. Replication of these results in independent cohorts would help establish their generalizability.
