The promise of genetics is that understanding and characterizing how genetic influences impact alcohol use outcomes will lead to improved prevention, intervention, and treatment. 130 Our efforts to map the pathways by which genetic factors influence alcohol use outcomes via intermediary behaviors and environmental factors have already led to the development of novel intervention approaches aimed at early indicators of risk, such as level of response to alcohol 66 , 131 , 132 and externalizing and internalizing characteristics. 133 These interventions target genetically‐influenced pathways of risk and can be tailored to an individual's risk profile.