Figure 1E ), and JPT (rs6916092; p = 0.016; Figure 1G ), and the second most significant functional SNPs in CEU-Parent (rs10943869; p = 0.017; Figure 1F ) and YRI-Child (rs3757350; p = 0.012; Figure 1H ) were all located in PHF3-PTP4A1. The peak SNPs among each of these populations were in high LD (D′>0.9); especially, the peak SNP in CHB (rs9294269) was exactly the same peak SNP in AAs ( Figure 1B vs. 1D ). The more closely the peak SNPs were located ( Figure 1I ), the correlations between the distributions of −log(p) values across whole region were more significant ( Table 2 ), which suggested that the peak SNP captured most information of the whole distribution across that region. The more significant those correlations were, the more consistent (replicable) between populations the risk regions would be. Thus, the distance between peak SNPs reflected the strength of replicability of association or function signals between populations.
