In the AA discovery sample, within the 25 Mb region around the peak association SNP (rs9294269; p = 1.6×10−5), this risk LD block formed the only peak that had association signals significant at a p<10−3; within the 90 Mb region around this SNP, this risk LD block was the only peak that had association signals significant at a p<10−4 (see Figure 1A , which depicts 10 Mb of this interval). In the EA replication sample, within the 10 Mb region around the peak SNP (rs9449312; p = 1.3×10−3), this risk LD block was the only peak that had association signals significant at a p<1.5×10−3 (see Figure 1C , which depicts 1 Mb of this interval). Additionally, within 1 Mb range, the most significant functional SNPs in HapMap CHB (rs9294269; p = 0.0023; Figure 1D ), CEU-Child (rs1681957; p = 0.0036; Figure 1E ), and JPT (rs6916092; p = 0.016; Figure 1G ), and the second most significant functional SNPs in CEU-Parent (rs10943869; p = 0.017; Figure 1F ) and YRI-Child (rs3757350; p = 0.012; Figure 1H ) were all located
