We found 68 GWS SNPs (Supplemental Figure 5), which are challenging to map to nearby regions or candidate genes due to ancestral differences in LD structure. Table 2 lists the SNP with the lowest GWAS p-value on each chromosome. The most significant association was noted near the FUT2 gene (rs507766, p = 3.47e-19). Many GWS signals were consistent with genes found in the European GWAS, including FTO (rs9928094, p = 6.50e-32) and PDE4B (rs1937439, p = 8.56e-12). We also identified two SNPs in genes which have previously been implicated in SUDs including CADM2 (rs62250713, p=1.00E-18) and FOXP2 (rs4727799, p=3.90E-15), both of which were within r2= 0.6 of lead signals from the European GWAS.
