The ASSET-based meta-analysis of GWAS data for AUD (N=82,705)11, tobacco dependence (based on the Fagerstrom Test for Nicotine Dependence, N=9,925)13, CUD (N=9,745)15, and OUD (N=32,088)16 in individuals of African ancestry yielded only 1 GWS pleiotropic SNP, rs77193269 (p=4.92e-8); this SNP was GWS for AUD and tobacco dependence when considering ASSET loci pleiotropic for 2 substances (Supplemental Figure 4B). For substance-specific signals, only one SNP was GWS significant: rs2066702, an ADH1B variant that was alcohol-specific (Supplemental Figure 4A).
