culture or religion can prevent individuals with high PGS from drinking, whereas traumatic events can increase the probability of AUD for those with low PGS). Consequently, higher PGS estimability is not expected for preventable diseases. It is noteworthy that the aforementioned ORs for both the AOU and IB cohorts (approximately 2) were near the suggested threshold for a PGS to be incorporated in clinical settings to provide additional information for risk evaluation.48,49
