Although female individuals have substantially lower AUD prevalence than male individuals,2 the PGS had similar results for both sexes in this study (Table 3). Therefore, this suggests that the different prevalence may be due to nongenetic factors. Studies have found that sex differences of AUD and related problems have decreased substantially in the US.50 Because both sexes show similar genetic risks for AUD development, identifying which drinking-related behaviors have changed in female individuals could shed light on the etiologies of AUD and mitigate AUD and related issues.
