Chunk #12 — Results — Mega-analysis — Cortical thickness and surface area differences between OCD patients and controls — Children:

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Cortical Abnormalities Associated With Pediatric and Adult Obsessive-Compulsive Disorder: Findings From the ENIGMA Obsessive-Compulsive Disorder Working Group.

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We found significantly thinner cortices in pediatric OCD patients (N=407) compared to controls (N=324) in bilateral superior parietal and left inferior parietal cortices (Figure 2) and left lateral occipital cortex (Cohen’s d between −0.24 and −0.31; Supplementary Table S6). None of the regions analyzed showed significant differences in cortical surface area or evidence of sex-by-diagnosis or age-by-diagnosis interaction effects (Supplementary Table S7).