For 34 of the 48 traits, at least one tissue was significant at FDR<5% (Figure 2, Figure S1 and Tables S5 and S6). Several of our results recapitulate known biology: immunological traits exhibit immune cell-type enrichments, psychiatric traits exhibit strong brain enrichment, LDL and triglycerides exhibit liver-specific enrichments, BMI-adjusted waist-hip ratio exhibits adipose enrichment, type 2 diabetes exhibits enrichment in the pancreas, and height exhibits enrichments in a variety of tissues in a pattern similar to previous analyses of this trait44. In addition, several of our results validate very recent findings from other genetic analyses: in particular, smoking status, years of education, BMI, and age at menarche show robust brain enrichments that recapitulate results from our previous analysis of genetic data together with chromatin data7. Our results were robust to the choice of percent of genes used (10%) and to the size of the window used (100kb) (Figure S2). We assessed correlations in enrichment patterns for pairs of traits (Online Methods), and found large and significant correlations among many brain-related phenotypes, among many immune-related phenotypes, and among a third set
