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Chunk #8 — RESULTS — Analysis of 48 complex traits across multiple tissues

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Heritability enrichment of specifically expressed genes identifies disease-relevant tissues and cell types.
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the size of the window used (100kb) (Figure S2). We assessed correlations in enrichment patterns for pairs of traits (Online Methods), and found large and significant correlations among many brain-related phenotypes, among many immune-related phenotypes, and among a third set of phenotypes including height and blood pressure that tended to have enrichments in the musculosketal/connective, cardiovascular, and other categories (Figure S3). The most significant annotation for each of these 34 traits spanned 11%-23% (mean 16%) of the genome and explained 21%-62% (mean 36%) of SNP-heritability, with enrichments varying from 1.4× to 4.7× (mean 2.3×) (Table S5).