The GWAS meta-analyses of ODexposed, ODunexposed, and OEcontrols phenotypes included up to 4,503 OD cases (African-ancestry=1,231; European-ancestry=3,272), 4,173 OE controls (African-ancestry=1,297; European-ancestry=2,876), and 32,500 OU controls (African-ancestry=7,063; European-ancestry=25,437). Significant SNP-heritability was observed for ODunexposed (liability-scale h2g=0.28, SE=0.1; population prevalence=0.01, sample prevalence=0.22), but not for ODexposed (liability-scale h2g=−0.08, SE=0.08; population prevalence=0.01, sample prevalence=0.55) and OEcontrols (liability-scale h2g=0.05, SE=0.1; population prevalence=0.05, sample prevalence=0.12). Moderate genome-wide inflation was observed in the European-specific meta-analyses, but genomic control using lambda or the LD score regression intercept did not affect the significance of any variants in the GWAS meta-analyses (Supplementary Table 4; Supplementary Methods).
