Glutamate receptors, including NMDA, are important for alcohol intoxication, sensitivity, and withdrawal. Some aspects of this system are different in individuals with alcohol dependent relatives and drinkers with low LR (Bell et al., 2016; Joslyn et al., 2010; Krystal et al., 2003; Schumann et al., 2008). Specific variants include rs2832407 in GRLK1 (GluR5) (chromosome 21q21.3) (Kranzler et al., 2009), the homolog of which is related to low alcohol consumption and high sensitivity in rodents (Bird et al., 2008); GRM3 (chromosome 7q21.11) rs6465084 (Xia et al., 2014) which might relate to oral alcohol induced body sway and to alcohol dependence (e.g., Wilhelmsen et al., 2003); and GAD1 (chromosome 2q31.1) for SRE-based alcohol sensitivity regarding rs2241165, rs2058725, and rs379185 (Kuo et al., 2009). Sensitivity might also relate to the FYN gene (chromosome 6q21), also known as protein tyrosine kinase [PTK] fyn, especially for T137346C regarding higher maximum drinks (a possible marker for a low sensitivity per drink) (Ishiguro et al., 2000; Schuman et al., 2003). PTK fyn knockout mice have a lower sensitivity to alcohol (Miyakawa et al., 1997). Effects of PTK
