117,272,386) encompassing rs2784 and neighboring top-ranking SNPs was identified by the D’ confidence interval algorithm employed in Haploview ver. 4.1 [Gabriel et al., 2002]. The pairwise r2 scores for rs2784 with other top-ranking TAOK3 markers (P < 1.0 × 10−5) range from 0.75 (rs7314987) to 0.97 (rs17512142). Results from a haplotype-based association test identified 14 different haplotypes within this 38 SNP LD block, with one of the haplotypes (frequency of 0.095) producing a highly significant P-value of 6.5 × 10−7.
