The genome-wide association results (−log10 P-value scores) for theta EROs are presented as a Manhattan plot in Figure 4, with SNPs displaying P-values less than 1.0 × 10−5 (N = 28) listed in Table II. The top-ranking SNP (rs2784) has a P-value of 2.4 × 10−7, falling short of the threshold for genome-wide significant association (Bonferroni-adjusted 5.3 × 10−8). This marker, along with ten other SNPs listed in Table II, are located within the intronic regions of TAOK3 on chromosome 12q24 (NCBI build 36.3 bp 117,071,989 – 117,295,133). This gene codes for TAO kinase 3, which is involved in MAP kinase (ERK and JNK) signaling pathways [Zhang et al., 2000] that play important roles in neuronal growth and differentiation [Rueda et al., 2002; Harada et al., 2004; Kanzawa et al., 2006]. A 199 kb “strong LD” block (bp 117,073,452 – 117,272,386) encompassing rs2784 and neighboring top-ranking SNPs was identified by the D’ confidence interval algorithm employed in Haploview ver. 4.1 [Gabriel et al., 2002]. The pairwise r2 scores for rs2784 with other top-ranking TAOK3 markers (P < 1.0 × 10−5)
