50 worm genes are orthologous to 50 genes in flies (identified by DIOPT scores ≥3 [Hu et al., 2011] and BLASTP searches [Altschul et al., 1997]). Of these 50 genes, only 7 (Adh, Clic, Dop1R1, iav, NPFR, Sir2, and slo) have been reported to influence behavioral responses to alcohol in flies. Similarly, the 91 fly genes that influence alcohol-related behavior are orthologous to 92 worm genes and only 8 of these (exc-4, exl-1, dop-4, npr-1, osm-9, sir-2.1, slo-1, and sodh-1) have been reported to be important for alcohol-related behaviors in worms. Presumably not all genes have been tested in both invertebrate models, and therefore, the overlap between genes in flies and worms described here probably underestimates the true genetic congruence in these 2 species.
