Two hundred and eleven individuals were screened to enroll 100 participants meeting all eligibility criteria. The participants were between the ages of 18–27 and consisted of 50 controls and 50 subjects with a lifetime cannabis-dependence diagnosis (74.0% with current and 26.0% with past cannabis dependence). Eligible subjects were healthy males and females with no history of major psychiatric or medical disorders and no current or sustained past (more than one month) psychotropic medication. The recruitment of otherwise normal, non-treatment-seeking subjects aimed to have a study sample representative of the general cannabis population, as opposed to other cannabis-abuse populations with psychopathology and neuropsychiatric comorbidities. Cannabis-dependent subjects and controls had similar racial breakdowns and only differed in the percentage of Hispanic participants and daily cigarette use ( Table 1 ). Among controls, 66.0% reported cannabis use at least once.
