A genome-wide gene-based association study conducted in Multi-Marker Analysis of GenoMic Annotation (MAGMA)49, mapped the GWAS SNPs to 17,840 protein coding genes and revealed 411 genes significantly associated with depression, after Bonferroni correction for the number of genes tested (P<2.8 x 10−6). A total of 314 significant genes were located in 141 of the 242 identified GWAS loci, while the remaining 97 significant genes were located outside these loci (Supplementary Table S7D). The most significant gene within each of the 141 genomic risk loci is labeled in Figure 1C.
