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Chunk #14 — MATERIALS AND METHODS — Models to Test of the Indirect Effect of Alcohol Exposure on Alcohol Problems through Network Connectivity Strength

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Reduced left executive control network functional connectivity is associated with alcohol use disorders.
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To test the indirect effect of alcohol exposure on alcohol problems via ECN connectivity strength, we tested the model in Figure 2 for the entire ALC sample in EQS Version 6.1 (Bentler and Wu, 2003). The dependent measure is a latent variable defined as alcohol problems with AUDIT and ICS-FC serving as indicators. As age and YRD were highly correlated in the ALC sample (r = 0.727, p < 0.001) we chose to use YRD as the sole exogenous variable in the model.