The aim of the current review was to summarize the state of knowledge regarding the regulation of endocannabinoid signalling by acute stress and glucocorticoids, and the functional role these changes may possess with respect to the neurobehavioral responses to stress and glucocorticoids. In addition to the data reviewed herein, there is a substantial body of research which has also demonstrated a complex role of endocannabinoid signalling in conditions of chronic stress (see (Gorzalka et al., 2008; Patel and Hillard, 2008) for reviews of this topic); however, this topic was beyond the scope of the current review.
