AN subtype analyses were included to determine whether differences might exist between the classic restricting subtype of AN and the subtype marked by dysregulation characterized by binge eating and/or purging behavior. These analyses had lower power due to the smaller sample sizes. Only two SNPs, rs1523921 (also found to be suggestively associated in the main case-control analysis) and rs10777211 located 333kb upstream of ATP2B1, showed association at the 10-5 significance level (Table S6). Similarly, subsequent analyses pertaining to associated phenotypes (weight regulation: BMI/obesity loci,40, 61, 69, 70 and loci for extreme obesity;61, 71, 72 psychiatric comorbidities: ADHD, schizophrenia, bipolar disorder, and major depressive disorder) or previous equivocal association findings for AN or eating disorders (AN variants,42 eating disorder related symptoms, behaviors, and personality traits variants59, 60) did not reveal significant findings. More adequately powered analyses that could allow us to detect variants that can distinguish between these two subtypes could be clinically meaningful in predicting clinical course and outcome and eventually in designing targeted therapeutics.
