Our expression studies further extend the GWAS findings. It is reasonable, althoughperhaps not essential, to expect that genes implicated in AN be expressed in the brain. Supporting this assumption, 32 mouse orthologues of 34 human genes identified as being of interest were expressed at least at a low level in mouse brain. Moreover, genes corresponding to the more strongly associated genetic variants tended to be more highly expressed. For example, high FPKM values for Ppp3ca, Cul3, and Sox2ot underscore that these genes may play a neuropsychiatric role.
