Several genetic variants were suggestively associated with AN (P<10-5) (Table 2). Two variants, rs9839776 in SOX2OT and rs17030795 in PPP3CA, were identified through analysis of all discovery and replication datasets. Two additional variants with P<10-5, rs1523921 located between CUL3 and FAM124B and rs1886797 located near SPATA13, were identified through analysis of individuals of European descent only (Table S5), suggesting either heterogeneity in the effects of these SNPs by ancestry or low power. The genes displayed in Table 2 are discussed in greater detail in the Supplementary Information; however, we highlight that four of these variants are neurodevelopmental genes that regulate synapse and neuronal network formation (SYN2, NCAM2, CNTNAP2 and CTNNA2) and two have been associated with Alzheimer's disease (SOX2OT and PPP3CA). Additionally, one of our prioritized SNPs (rs6558000) (Table S5) is located in close vicinity (9kb upstream) of the EPHX2 gene that was recently identified as a susceptibility locus to AN through candidate gene sequencing study of early-onset severe AN cases and controls.43
