Hence, the association between HTR7 and alcohol dependence represents a novel insight into the genetic underpinnings of the disorder. Alcohol dependence is considered to be part of a wider spectrum of disinhibitory disorders that include externalizing behavior and substance abuse, with many neurochemical factors and pathways contributing to co-occurring disinhibitory personality traits. Presently, several common genetic determinants for neural oscillations and alcohol dependence have been discovered in the GABAergic, cholinergic, and glutamatergic systems (GABRA2, CHRM2, and GRM8, respectively). Based on the results of the present study, as well as pharmacological research [Buhot et al., 2000], the serotonergic system may serve as a key modulator of these interactive neuroelectrical systems, involved in different “cognitive pathways”, such as memory and learning processes, with the hippocampus and frontal cortex serving as the main target structures [Frodl-Bauch et al., 1999; Cifariello et al., 2008]. Moreover, administration of 5-HT7 antagonists in adolescent rats has been shown to enhance behavioral impulsivity, while agonist-induced activation of endogenous 5-HT7 significantly increased neurite length in striatal neuron primary cultures, suggesting remodeling of neuronal plasticity in brain reward circuits [Leo
