Individuals with higher AD PRS (p < 0.001 threshold) also demonstrated deficits in neuropsychological performance, including poorer planning and problem solving skills on the Tower of London task (B: −0.097, p < 0.001) and visuospatial memory and working memory on the visual span test (forwards span B: −0.123, p < 0.001), and had an increased number of symptoms for DSM-5 AUD (B: 0.087, p < 0.001) and opioid use disorder (B: 0.069, p < 0.001), but not cannabis or cocaine use disorders (B: 0.43, p > 0.1, B: 0.037, p > 0.1 respectively). While the magnitude of these associations was reduced when maximum number of drinks per week were included in regression models, all associations remained significant (Table 3).
