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Chunk #28 — 3. Results

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Association of Polygenic Liability for Alcohol Dependence and EEG Connectivity in Adolescence and Young Adulthood.
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Sensitivity models were only examined in males. PRS-EEG coherence association models including maximum number of drinks consumed in a typical week and DSM-5 AUD as covariates, results were largely unchanged (Supplemental Tables S5 and S6, respectively). Models stratified by DSM-5 AUD diagnosis show that the patterns of PRS-EEG coherence associations differed among the two groups; among those with alcohol use disorder, prominent associations with fronto-central, tempo-frontal (F3-C3–F7-T7, FZ-CZ–F3-C3), centro-parietal (C4-P4–C3-P3, C3-P3–CZ-PZ), parietal-occipital (P4-O2–P3-O1), and fronto-parietal (P8-P4–F8-F4) high alpha coherences are observed only among males from ages 18–24 (Supplemental Figure S4, panel A), whereas prominent associations are only observed with parietal-occipital (P4-O2–P3-O1) high alpha coherences among males from ages 24–31 (Supplemental Figure S4, panel B).