The genome-wide genetic correlation (rg) of BD with a range of diseases and traits was assessed on LD Hub48. After correction for multiple testing, BD showed significant rg with 16 traits among 255 tested from published GWAS (Supplementary Table 15). Genetic correlation was positive with all psychiatric disorders assessed, particularly schizophrenia (rg = 0.68) and major depression (rg = 0.44), and to a lesser degree anorexia, attention deficit/hyperactivity disorder, and autism spectrum disorder (rg ≈ 0.2). We found evidence of positive rg between BD and smoking initiation, cigarettes per day, problematic alcohol use, and drinks per week (Fig. 3). BD was also positively genetically correlated with measures of sleep quality (daytime sleepiness, insomnia, sleep duration) (Fig. 3). Among 514 traits measured in the general population of the UK Biobank, there was significant rg between BD and many psychiatric-relevant traits or symptoms, dissatisfaction with interpersonal relationships, poorer overall health rating, and feelings of loneliness or isolation (Supplementary Table 16).
