Chunk #101 — 3 Neuropeptide Roles in Acute and Chronic Alcohol Actions — 3.1 Corticotropin-Releasing Factor — 3.1.2 Corticotropin-Releasing Factor Actions in the Central Amygdala
CRF1Rs mediate the EtOH-induced augmentation of IPSCs in mouse CeA (Nie et al. 2004; Nie et al. 2009) via the PKCε signaling pathway (Bajo et al. 2008; Nie et al. 2004). Both CRF and EtOH augment evoked IPSCs in mice CeA neurons, and CRF1R (but not CRFR2) antagonists blocked both CRF and EtOH effects. In addition, CRF and EtOH augment IPSCs in wild-type and CRF2R knockout mice, but not in CRF1R knockout mice (Nie et al. 2004).
