To provide a new model of binge-like drinking, we bred a mouse line for high blood ethanol levels due to High DID (HDID), starting with a large population of a genetically heterogeneous stock, HS/Npt, derived from intercrossing 8 standard inbred strains. Each generation, mice were given a 2 day DID test, with access to 20% ethanol (v/v) in a single bottle for two hr on the first day, and four hr on the second day, starting 3 h after the onset of their circadian dark. Each generation, selection of breeders was based on their BEC at the end of the second day of drinking, and mice with the highest BECs were mated to produce the next generation. We recently reported the results from the first replicate line (HDID-1) for this selection project (Crabbe et al. 2009). When compared with mice offered water, the HDID-1 mice were shown to be intoxicated in the balance beam test. The heritability estimated from the realized response to selection after 11 selected generations was h2 = 0.09, and the relatively slow rate of response suggests
