These studies suggest that the DID phenotype is not primarily related to feeding behavior, or at least to calorie-seeking (Lyons et al. 2008). In another application of the method, Boehm et al. have used the DID procedure to offer high ethanol concentrations to pregnant C57BL/6J mice in an attempt to model binge-like consumption (Boehm et al. 2008). These animals reached BECs of 118–182 mg%, sufficient to produce behavioral changes in adolescent offspring. The authors suggest that the procedure may be useful for animal model studies of Fetal Alcohol Spectrum Disorders.
