Meta-analysis of the results from the EA and AA subsamples did not yield a boost in statistical significance (Table 3). This was evident from a comparison of results in the EA and AA subsamples. Of all SNPs with p-values < 0.05 in EA subsample, only 5% had corresponding p-values < 0.05 in AA subsample. However, particularly for the SNPs for the EA subsample shown in Table 2, the direction of effect in the AA subsample predominantly (with the exception of 5 of 20 SNPs) concurred with the EA subsample.
