Individual signals did not surpass the Bonferroni corrected genome-wide significance threshold of p < 5×10−8. The results for the top 20 SNPs are presented in Table 3 (the top 100 results for the EA and AA subsamples are available in eTable 2 and 3, respectively2). For the EA subsample, 11 SNPs on 17q23-24 appeared to be associated at nominal levels of significance although none surpassed the genomewide threshold of 5×10−8.The top SNP, rs6504555, was an intronic variant in the bromodomain PHD finger transcription factor (BPTF) gene – a regional association plot for this region of chromosome 17 is shown in Figure 1, indicating a high degree of linkage disequilibrium across the associated SNPs. With the exception of rs11870068, the remaining chromosome 17 SNPs were in moderate to high linkage disequilibrium (r2 ranging 0.66 to 1.0). In the AA subsample, results did not aggregate in any particular chromosomal region. The most significant SNP, rs4364205, on chromosome 3, was intergenic.
