2017; Spyropoulos et al., 2018). Concerning sleep disorders, patients with obstructive sleep apnea had significantly lower theta–gamma PAC in the sensorimotor cortex at all sleep stages (Gouveris et al., 2022). Moreover, one study used PAC and amplitude‐amplitude coupling (AAC) to classify seven sleep disorders with 74% accuracy (Dimitriadis et al., 2021). Although PAC has not been extensively studied in ID, multiple converging lines of evidence support it as an important synchronization measurement that can be considered a promising marker of the neurophysiological mechanisms of ID.
