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Chunk #14 — Methods and Materials — Data analysis

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Rare nonsynonymous variants in alpha-4 nicotinic acetylcholine receptor gene protect against nicotine dependence.
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STRUCTURE software (30-32) set at 500,000 burn-in iterations and 500,000 repeats, was used to analyze the AIMs data. Subjects with ancestry proportion scores ≥ 0.50 were classified as AA, and those with ancestry proportion score <0.50 were classified as EA. The results were highly concordant with self-reported race.