Chunk #26 — Results — Studies in P and NP Rats — Presynaptic/synaptic genes

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GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats.

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Table 2 and Figure 1B: In common with the alcoholics and cocaine addicts, P rats show significant down-regulation of GABBR1 (p = 0.025) (Figure S2) compared with NP rats. In addition, they showed a trend effect for up-regulation of genes implicated in GABA synthesis: GLS (p = 0.050) and GAD1 (p = 0.050) and significant down-regulation of ABAT (p = 0.030) that plays a role in GABA metabolism.