Similar to the cocaine addicts and alcoholics, P rats show a significant difference in expression of GABRG2 (p = 0.03). However this gene was up-regulated in P rats but down-regulated in alcoholics and cocaine addicts (Figures 2B and S2). P rats also show up-regulation of GABRG3 (p = 0.025) together with a trend down-regulation of GABRB3 (p = 0.050).