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Chunk #27 — Results — Studies in P and NP Rats — GABAA receptor subunit genes

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GABAergic gene expression in postmortem hippocampus from alcoholics and cocaine addicts; corresponding findings in alcohol-naïve P and NP rats.
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Similar to the cocaine addicts and alcoholics, P rats show a significant difference in expression of GABRG2 (p = 0.03). However this gene was up-regulated in P rats but down-regulated in alcoholics and cocaine addicts (Figures 2B and S2). P rats also show up-regulation of GABRG3 (p = 0.025) together with a trend down-regulation of GABRB3 (p = 0.050).