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Chunk #31 — Results — META-ANALYSIS

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Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
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No genome-wide significant result was observed. Figure 2 illustrates results for all genotyped and imputed SNPs. Table 5 (Broad) and Table 6 (Narrow) summarize results for all regions with at least one SNP with P < 10−5. Results for SNPs with P < 10−3 in any analysis are provided in online files meta-analysis_broad_supplementary_data.txt and meta-analysis_narrow_supplementary_data.txt. The Annotation columns of Tables 5 and 6 provide information about the closest gene (within 250 kb) or other functional elements annotated in the UCSC browser (full gene names and summaries of known functions are provided in Supplementary Results). For all regions with no genes or elements listed, peaks of high homology with known regulatory sequences were detected by the ESPERR (evolutionary and sequence pattern extraction through reduced representations) method for estimating regulatory potential.41