characterize the potential role of CYP2E1 in the advancement of NAFLD and development of NASH by using Cyp2e1-null mice as a negative control in high-fat diet (HFD)-mediated NASH models. The aim of this study was to examine this hypothesis by feeding wild-type (WT) and Cyp2e1-null mice with a HFD for 10 weeks. Steatosis, inflammatory response, oxidative stress, systemic IR and the indicators of NAFLD and NASH manifestations were monitored in both WT and Cyp2e1-null mice fed a HFD or a low-fat diet (LFD).
