We assessed AVPR1A gene expression in RNA from the prefrontal cortex of the control group from the Stanley Medical Research Institute sample. The Stanley Foundation Brain Collection sample was genotyped for rs11174811 polymorphisms, which is located within the seed sequence of two miRNAs (hsa-miR-578 and hsamiR-526b) predicted to bind to the 3′ untranslated region of the AVPR1A gene. The minor allele of this polymorphism is expected to disrupt the miRNAs binding and thus release the inhibitory effect of hsa-miR-578 and hsa-miR-526b on AVPR1A expression levels.
