Neurons have a unique organization of their secretory pathway, with membrane and lipid processing in somatic Golgi, and additional ER-to-Golgi transport in dendrites [41], which enables dendrites with Golgi to be longer and more complex [42]. In that context, the shared increases in transcription of genes relating to ER and Golgi synthesis and processing, and decreased transcription of genes invested in other transport functions is interesting, and suggests that changes in aPFC dendritic function and plasticity is shared among drug abuse cases.
