greater than 0.50, indicating moderate-to-large magnitude group differences. Parietal WM volume in PSU correlated positively with prior year cocaine use, suggesting a substance-related parietal WM volume expansion. Frontal, parietal, and total cortical GM volumes were associated with some critical neurocognitive domain measures in both PSU and ALC, but not in LD. These neuroimaging abnormalities may serve as polysubstance abuse biomarkers and as potential targets for pharmacological and behavioral PSU-specific treatment aimed at decreasing the high relapse rates in PSU.
