The current study follows up the COGA genome-wide significant association of KCNJ6 SNPs with theta EROs to targets during a visual oddball paradigm to determine its association with theta EROs during reward processing in a monetary gambling task, a phenotype similar to the one used in the original study, but tapping different neural processes, in order to determine if there is an association with theta EROs during a different task. The overall goal of the present study is to investigate the genotypic effects of a KCNJ6 SNP (rs702859) on theta EROs during reward processing in subjects (17–25 years old) in the COGA Prospective study. This age range was selected as the study by Chorlian et al. (in press) indicated that the effects of this SNP on theta EROs were strongest in this age range of the prospective study. The rationale for selecting rs702859 was three-fold: (i) this SNP had a genome-wide significant association with theta ERO in the previous GWAS study; (ii) this SNP was in high LD with the top genome-wide significant genotyped SNPs, and (iii) this was the