for selecting rs702859 was three-fold: (i) this SNP had a genome-wide significant association with theta ERO in the previous GWAS study; (ii) this SNP was in high LD with the top genome-wide significant genotyped SNPs, and (iii) this was the only exonic genomewide significant SNP in the KCNJ6 gene. Given that there is empirical evidence showing relationships between (i) KCNJ6 and the reward system, (ii) theta EROs and the reward system, and (iii) KCNJ6 and brain oscillations, the primary hypothesis of the study is that variations in rs702859 genotypes will influence theta ERO power during loss and gain processing. In the current study, the term ‘reward processing’ is being used to mean neurocognitive processing related to both loss and gain, and any effect/context specific to either loss or gain will be properly mentioned. We expect that the findings from this study of variations in the KCNJ6 gene on reward-related theta EROs may help to further our understanding of these genetic effects on reward processing and possible neurocognitive, behavioral and clinical implications.
